Current Research

• Distributed multipole analysis (Computational chemistry)

Past Research

• Solvation free energies of amino acids using the cluster continuum model (Computational chemistry)
• Monomer synthesis of telomerase-inhibiting ligand for binding to telomeric RNA g-quadruplex (Chemical biology)
• Literature review on dye sensitised solar cells

Academic Interest

• Computational chemistry: Distributed multipoles, solvation studies
• Keen on writing programs for comp chem. using Fortran
• Would not mind venturing into physical chemistry or inorganic chemistry as well

Specialisation: Computational biology 

Current Research

• Self-organization of actin network through actomyosin contractility, formin-driven actin polymerization, and filamin-mediated cross-linking

Past Research

• Environmental sensing and motility of hMSC cells on three dimensional nanotopography
• Computer aided model of survival pathways in LNCaP cells
• Cross-talks in Apoptosis: perspective in cancer study
• Heat Shock Effect on Angiogenesis
• Neuron Induction in Embryonic Stem Cell
• Understanding the psychological effects of power and status on people in interactions: data mining

Academic Interest

• Cytoskeleton generates coordinated forces that enable the cell to move and change shape. I am interested in the study of actin cytoskeletal mechanics, and working to identify, measure, and describe how the forces for motility and morphogenesis are expressed at the molecular and cellular level. I am experienced in cytoskeleton dynamics and mechanobiology; familiar with the technologies such as micro-fabrication, advanced cellular imaging (Confocal, TIRF, PALM&STORM) and imaging data analysis; with some experience of Fluorescence correlation spectroscopy and Cryo-electron microscopy and tomography
• Mechanobiology: the study of molecular, cellular and tissue mechanics
• Working to identify, measure, and describe how the forces for motility and morphogenesis are expressed at the tissue, molecular and cellular level
• Cell migration and actin cytoskeleton
• Cell adhesion to extracellular matrix and other cells
• Microtubules and molecular motors
• Signaling in cell mechanosensing, polarization and migration
• Computational biology: computational modelling of cell signalling pathways

Specialisation: Computational biology 

Current Research

• System level multiple target drug discovery
• Data mining and machine learning techniques for analyzing drug like properties

Past Research

• In silico drug design
• Microarray primer design
• Computational neuroscience

Academic Interest

• Computational biology and bioinformatics
• Systems biology
• Machine learning
• Data mining

Specialisation: Computational biology (Molecular epidemiology) 

Current Research

• Developing new method for identifying very recent positive selection across human genome

Past Research

• Motif module discovery using chip-seq of transcription factors in correlation with gene expression: a breast cancer case study

Academic Interest

• Computational genomics
• Molecular epidemiology

Specialisation: Infectious diseases 

Current Research

• Influenza virus and therapy research beased on host factors

Past Research

• Exploring novel treatments for influenza infection
• in vitro and in vivo activities of visperin in influenza infection

Academic Interest

• Host factors as a component for antiviral therapy
• Small RNAs (miRNAs and siRNAs) and their physiologival role in viral diseases
• Gene therapy, DNA vaccines and in vivo plasmid/vector therapy models for viral diseases
• Virology and infectious diseases
• Cell biology and microbiology

Specialization: Biochemistry 

Current Research

• Regulation of histone demethylases leading to altered gene expression and tumour progression (Epigenetics and cancer)

Past Research

• Metastasis and cancer
• Effect of collagen inhibitors in angiogenesis in zebrafish models

Academic Interest

• Cancer, protein stability and ubiquitination, drug discovery, pharmacology, epigenetics

Publications

• DP Wong, G Wells, T Hagen. Heteroaromatic 4-arylquinols are novel inducers of Nuclear factor-erythroid 2-related factor 2 (Nrf2). Eur J. Pharmacol. 643:188-94 (2010)
• DP Wong, G Wells, T Hagen.The Induction of Phase 2 Response in Chemoprevention by Heteraromatic Quinols. 15th (NUROP) National Undergraduate Research Opportunities Programme Congress (2010)

Specialisation: Molecular cell biology 

Current Research

• Developmental origins of health and disease (DOHaD)
• DNA Methylation studies
• Gestational Diabetes
• http://devos.sg/teamDevOS/postgraduate.html#ives

Past Research

• Cancer angiogenesis
• Zebrafish embryogenesis
• Gastric cancer proteomics
• Influence of microbiota on the epigenetics of gut

Academic Interest

• Ecological biogeography and marine biology

Specialization: Integrated biology and medicine 

Current Research

• Health economics and health services.

Past Research

• Mitochondria dysfunction and Parkinson’s disease (neuroscience).
• Apoptosis during neuronal development.
• Histone variants in embryonic stem cell differentiation (epigenetics).
• Ex vivo expansion and in vivo reconstitution of hematopoietic stem cells (stem cell, immunology).

Academic Interest

• Health economics, stem cells, epigenetics, immunology, neuron science and behavioral studies.

Specialisation: Molecular cell biology 

Current Research

• Proteomic analysis of molecular signaling pathways involved in the protection of the myocardium from ischemic-reperfusion injury by postconditioning in an in vitro model.

Past Research

• Studying the roles of a novel protein, Aph2, in DNA damage signaling pathways.
• Roles of saturated fatty acids in DNA damage signaling pathways.

Academic Interest

• Molecular and Cell Biology:
• Understanding and elucidating protein signaling pathways which are important for the proper development of an organism.
• Identifying cellular survival cascades that are activated by respective treatments to protect the cell from further injuries which lead to cell death.
• DNA damage signaling cascade and DNA repair mechanisms.
• Autophagic progresses of the cell.
• Functions of miRNA in the proper development of an organism.

Specialisation: Environmental biology 

Past Research

• Proteomic analysis of molecular signaling pathways involved in the protection of the myocardium from ischemic-reperfusion injury by postconditioning using an in vitro model.
• Elucidating factors affecting sedimentation in mangroves.

Academic Interest

• Terrestrial Ecology.
• Geosciences.
• Issues that involve interdisciplinary studies – particularly the physical environmental and its effects on biological issues.

Specialisation: Molecular Cell Biology

Current Research

• Production of biomolecules from photosynthetic microalgae 
• Genetic engineering of microalgae

Past research

• Pathogenesis of the rice blast fungus Magnaporthe grisea
• Production of biofuel from microalgae

Academic Interest

• Microbiology and biotechnology

Current Research

• Quantum nonlocality and thermodynamics

Academic Interest

• Quantum mechanics- Entanglement, teleportation, decoherence , no cloning theorem, quantum-classical correspondence
• Group theory and symmetry in physics

Current Research

• Quantum Cryptography (reference frame independent protocol with higher dimensional coding)

Academic Interest

• Nonlocality (quantum set and Bell’s inequality)
• Quantum information in general

Current Research

• Quantum Bell’s inequality (CGLMP), polytope and dimension witness

Academic Interest

• General physics especially quantum mechanics
• Crytography

Current Research

• Radial Mirror Analyzers in Scanning Electron Microscopes (ECE)
  

Past Research

• An Investigation of the existence of closed timelike curves and the feasibility of time travel
• Making sense of time travel paradoxes in van Stockum space-time
• Ising model in teaching-learning processes
• HBT effect in thermal light sources

Academic Interest

• Particle physics
• General relativity
• Electron optics
• Computational Physics

Current Research

• Polarization-entangled photon pairs on satellite system (Experimental)

Past Research

• SP2171:The definition of a second and the atomic clock (Literature review)
• PC3180: Mode-locking laser and Frequency comb (Literature review)
• SP2172: Stellar interferometer using Hanbury Brown and Twiss (HBT) Effect (Experimental)
• UROPS: Quantum teleportation using three-particle entanglement in non-inertia frame (Theoretical)
• ISM: Advanced General Relativity (Theoretical)
• FYP: Quantum Revival in open systems (Theoretical + Computational)

Current Research

• Spin and charge transport in nanostructures

Academic Interest

• Computational physics
• Condensed matter physics 
• Nanoscience and nanotechnology

Current Research

• microwave photonics : application of cloaking device

Past Research

Academic Interest

Current Research

• Biomechanics (cell-cell junction, start from Aug 2012)

Past Research

• Biomechanics (inflammation, atherosclerosis and stents) (2010 – 2012)
• Quantum information (preserve coherence of entangled qubits)(2008-2010)

Academic Interest

• Biomechanics/biophysics
• Biology in general
• Macrophysics (in particular soft matter)
• Other physics (but not mathematical or computational physics)